Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid

Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid

BACKGROUND Gambogic acid (GA) was extracted from the dried yellow resin of gamboge (Garcinia hanburyi) which is traditionally used as a coloring material for painting and cloth dying. Gamboge has been also used as a folk medicine for an internal purgative and externally infected wound. We focused on the mechanisms of apoptosis induction by GA through the unfold protein response (ER stress) in H...

Keywords: Gambogic acid, anticancer, ER stress, Apoptosis, HeLa cells

Apoptosis induction in acute promyelocytic leukemia cells through upregulation of CEBPα by miR-182 blockage

MicroRNAs (miRNAs) involved in regulation of the genes. The CCAAT/enhancer-binding protein-α (CEBPα) is a crucial transcription factor for normal hematopoiesis and cell cycle that frequently disrupted in human acute myeloid leukemia (AML). The miR-182 up-regulation in several malignant diseases such as AML was reported, in the other hand bioinformatics analysis revealed CEBPα targeted by miR-18...

Goniothalamin induces mitochondria-mediated apoptosis associated with endoplasmic reticulum stress-induced activation of JNK in HeLa cells

Goniothalamin, a natural occurring styryl-lactone isolated from Goniothalamus macrophyllus (Blume) Hook. f. & Thomson var. macrophyllus, can trigger cancer cell death in various types of cancer cell. The present study focused on elucidation of the mitochondria-mediated apoptosis associated with endoplasmic reticulum (ER) stress-induced activation of c-Jun NH2-terminal kinase (JNK) by goniothala...

P42: Luteolin Counteracts ER Stress in PC12 Cells through Moderating ER Chaperones and Heat Shock Proteins

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